Learnings from Protein Folding Projected onto Amyloid Misfolding
نویسندگان
چکیده
منابع مشابه
Transient misfolding dominates multidomain protein folding
Neighbouring domains of multidomain proteins with homologous tandem repeats have divergent sequences, probably as a result of evolutionary pressure to avoid misfolding and aggregation, particularly at the high cellular protein concentrations. Here we combine microfluidic-mixing single-molecule kinetics, ensemble experiments and molecular simulations to investigate how misfolding between the imm...
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ژورنال
عنوان ژورنال: ACS Chemical Neuroscience
سال: 2019
ISSN: 1948-7193,1948-7193
DOI: 10.1021/acschemneuro.9b00445